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A new definition of Alzheimer’s disease?
In an opinion published in The Lancet Neurology, a group of international experts has proposed a new definition of Alzheimer’s disease. The aim is to achieve earlier diagnosis. Up to now, diagnosis was not given until the onset of proven dementia.
Professor Bruno Dubois of INSERM’s Unit 975 (Pierre and Marie Curie University – Pitié Salpêtrière Group, Paris) is therefore proposing that the condition be redefined as a clinicobiological syndrome. “Diagnosis can now be made using biomarkers that are easy to identify in patients, even at a very early stage of the disease”, he explains. It could be a matter of episodic memory problems, for example. Difficulty learning a list of words could be considered as a sign. But it is also the case that certain biological signs, and a positive result on just one of these biomarkers could be considered sufficient.
These new criteria will make it possible “not to have to wait any longer for a patient to develop proven dementia and not to go on excluding many sufferers from diagnosis and (therefore) from treatment”.
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