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8 February 2012








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Weight and hormones

[13 August 2008 - 10h12]

Do you have a large appetite? Do you have difficulty losing weight and especially not putting it back on? It could all be down to hormones!

  • First – leptin. This is produced by our adipose cells. When leptin is at a normal level, we eat just what we need to maintain our weight. But when it decreases, after a large weight loss for example, our brain sends a message to our body telling it that it needs to eat to regain its previous weight.
  • Next – ghrelin. This is produced by the stomach and the small intestine. This hormone makes you feel very hungry and can make you consume as much as 30% more calories than usual. Here again, ghrelin levels increase in people who are on a weight loss diet.
  • Then - peptide YY3-36. This is produced by the cells of the intestine in response to the ingestion of food. An increase in this hormone sends a signal to the brain to remove the desire to eat.
  • Finally – neuropeptide Y. This acts as a central nervous system transmitter and stimulates appetite.


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